Arrowhead and Takeda Announce Topline Results from SEQUOIA Phase 2 Study of Fazirsiran in Patients with Alpha-1 Antitrypsin Deficiency-Associated Liver Disease

Just a couple of days back, the FTC came back with a similar order that requires Broadcom to stop conditional access to its chips. The order also prohibits Broadcom from retaliating against customers for doing business with its competitors. Broadcom settled the score with European regulators in October last year. The company was asked to suspend all existing agreements containing exclusivity or quasi-exclusivity agreements.

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Broadcom also agreed to suspend such exclusivity agreements and comply with it for a period of seven years. As Broadcom grew in stature, it signed long-term agreements with at least 10 OEMs that would give it close to a monopolistic stranglehold in the market. These agreements prevented the OEMs from buying chips from Broadcom’s rivals. Charges were pressed against global semiconductor manufacturer Broadcomby the US Federal Trade Commission for its monopoly over semiconductor components. This development might be the proverbial straw that broke the camel’s back as far as Broadcom is concerned.

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• The highest Arrowhead Pharmaceuticals, Inc. stock price was $ 51.11 till 9th Apr 2023 within the past 52 weeks.
• Arrowhead Pharmaceuticals, Inc. is a biopharmaceutical company, which engages in the development of medicines that treat intractable diseases by silencing the genes that cause them.

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Investing.com – U.S. equities were higher at the close on Wednesday, as gains in the Healthcare, Financials and Basic Materials sectors propelled shares higher. Investing.com – U.S. equities were higher at the close on Friday, as gains in the Technology, Consumer Services and Healthcare sectors propelled shares higher. Broadcom’s agreements enforced exclusivity and were adversely impacting the OEMs given the semiconductor shortage is expected to last for the next two, maybe even three years. The timing of this verdict is especially critical, given it has come in the middle of a massive semiconductor shortage worldwide which has exacerbated different companies’ ability to source chips from suppliers.

It is also among the few major suppliers of chips used in set-top boxes and cable broadband devices. Its direct customers include those Original Equipment Manufacturers, which use its components to build broadband devices. The price-to-book ratio is a company’s current market price to its Book Value.

About the company

In 2018, the FTC took an exception to this sort of arrangement and started probing the company. At issue was Broadcom’s near-monopoly on the sale of three types of semiconductor components or chips used in devices that deliver television and broadband internet services. TuteeHUB is a cloud based ecosystem for all to “Learn, Work & Earn” using integrated tools and hosted products and services. Arrowhead Pharmaceuticals, Inc. is listed on the NASDAQ stock exchange.

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Outside the U.S., Takeda will lead the global commercialization strategy and receive an exclusive license to commercialize fazirsiran with Arrowhead eligible to receive tiered royalties of 20-25% on net sales. Arrowhead received an upfront payment of $300 million and is eligible to receive potential development, regulatory and commercial milestones up to $740 million. These data are consistent with results from the Phase 2 AROAAT-2002 open-label study that were previously published in TheNew England Journal of Medicine. Additional details on the SEQUOIA study will be provided at a future scientific meeting.

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This feature allows them to be used in confined areas with ease. Individuals with the homozygous PiZZ genotype have severe deficiency of functional AAT that may lead to pulmonary disease and liver disease. Lung disease is frequently treated with AAT augmentation therapy. However, augmentation therapy does nothing to treat liver disease, and there is no specific therapy for hepatic manifestations. There is a significant unmet need as liver transplant, with its attendant morbidity and mortality, is currently the only available cure.

Silicon as the new gold has been much sought-after by everyone from carmakers to video game console manufacturers to even crypto miners. Broadcom was acquired by Avago Technologies in 2015 for $37B. The acquired company took the name Broadcom and built a substantial portfolio within the semiconductor business through a series of acquisitions. Over the years, Broadcom has built up a list of key clients like Apple , Hewlett-Packard , IBM, Motorola, Dell, Lenovo among many others.

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There were no treatment-emergent adverse events leading to drug discontinuation, dose interruptions, or premature study withdrawals in any study group. Compared with placebo, no dose-dependent or clinically meaningful changes were observed in pulmonary function tests over 1 year with fazirsiran. Alpaca Securities LLC, a member of the Securities Investor Protection Corporation, will transmit your orders to the stock exchange and will serve as the custodian for your securities account. In the event that Alpaca Securities LLC fails, and is placed in liquidation under the Securities Investor Protection Act, securities in your brokerage account may be protected up to $500,000.

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